Highly crystalline PCL ultrathin films as thermally switchable biomaterial coatings

Semi-crystalline oligomers are explored as functionalized thermoswitchable coatings for modification of biomaterials surface. Highly crystalline oligo(ε-caprolactone) (OCL) films prepared at the air–water interface by Langmuir technique, which consist tightly packed single crystals. Their morphology and melting temperature can be tuned chemical structure OCL end-groups (hydroxy or methacrylate) crystallization (12 21 °C) physical parameter. This demand high crystallite density adjustable is not met conventional methodologies preparing thin films, e.g., spin coating, spray solvent evaporation. The crystallinity reduces enzymatic degradation rate on both water solid surfaces. methacrylate crystal surfaces enables post-functionalization, was demonstrated using fluorescein dimethacrylate chemically linked label. thermoswitching behavior (melting recrystallization) functionalized, highly shows temperature-dependent distribution moieties, accumulated crystals, homogeneously dispersed when crystals molten. Thermally switchable relevant cell substrates modulating adhesion biointerface barrier layer influencing rate.